PhD student in Biomedical engineering / applied mathematics
Contract type : Public service fixed-term contract
Level of qualifications required : Graduate degree or equivalent
Fonction : PhD Position
Inria, the French National Institute for computer science and applied mathematics, promotes “scientific excellence for technology transfer and society”. Graduates from the world’s top universities, Inria’s 2,700 employees rise to the challenges of digital sciences. With its open, agile model, Inria is able to explore original approaches with its partners in industry and academia and provide an efficient response to the multidisciplinary and application challenges of the digital transformation. Inria is the source of many innovations that add value and create jobs.
About the research centre or Inria department
The team Carmen develops mathematical models and numerical methods in order to simulate the propagation of the cardiac action potential, from the cellular scale to the scale of the body. It is part of the IHU LIRYC, the electrophysiology and heart modeling institute in Bordeaux. It collaborates actively with the clinical, imaging, cellular electrophysiology, and signal processing groups within the LIRYC. Carmen aims at improving:
- our knowledge and the treatment of electrical cardiac pathologies;
- the exploitation of all available electrical signals.
The overall objectives of Carmen pertain both to the fields of numerical sciences, and to medical sciences through close collaborative research. The objectives in numerical sciences concern the progress to be made on data- and image-based modeling of cardiac electrophysiology, and model-based inverse reconstruction or interpretation of electrical signals. The goal in medical sciences is to contribute to the objectives of LIRYC concerning atrial fibrillation, sudden cardiac death due to ventricular fibrillation, and heart failure. Software tools are important for the success of this research.
For more informations : https://team.inria.fr/carmen/
Project CALM – Patient-specific modeling for accurate noninvasive and semi-invasive localization of ventricular ectopie – in partnership with IHU Liryc, Institute for Cardiac Rhythmology and Modeling, Co-funded by the Région Nouvelle-Aquitaine. The project is directed by a consortium of cardiologists and biomedical engineers, who will support the PhD student with their specific expertise. Training in scientific methods, literature research, and scientific writing is of course included in the PhD position. Travel expenses to present work at international scientific meetings are foreseen in the project.
Ventricular tachycardia (VT) is a life-threatening cardiac arrhythmia that often occurs in patients who previously suffered a myocardial infarction, but also in those with inheritable or congenital heart diseases and in apparently healthy subjects whose first symptom may be a sudden cardiac arrest. Endocardial catheter ablation is a possible treatment for VT. It has the advantage that it can permanently cure the patient. However, a catheter ablation procedure is costly and difficult, and does not always succeed. Methods to tell the cardiologist precisely where the arrhythmia comes from would greatly facilitate this procedure, making it faster and allowing to treat more difficult cases.
Ablation procedures are always performed with “electroanatomical mapping” systems, which tell the cardiologist precisely and in real time where the catheters are located in the heart. Our idea is to use live electrocardiogram (ECG) data to pinpoint, in the same system, where the catheter should go in order to reach the arrhythmia origin.
We have already generated testing data using in-silico models of several individual patients. With these data we have been able to show that our proposed method works well especially in the left ventricle of the heart. But this is just the first step. Next, we need to evaluate this method with clinical data and to integrate it in the workflow of the catheterization laboratory. Signal processing problems will have to be solved and interfacing both with existing equipment and with the users will have to be designed. The efficacy of the resulting system will have to be evaluated and compared to existing methods, and various improvements in the algorithm can be tested.
For this project we offer a 3-year PhD student position. Funding for this position has been obtained from the Région Nouvelle-Aquitaine, co-financed by IHU LIRYC – the institute of cardiac rhythmology and modeling in in Bordeaux. The PhD student will be directed by Dr Mark Potse (Carmen team, Inria Bordeaux) and co-directed by Prof. Pierre Jais (cardiologist, CHU de Bordeaux) and Dr Hubert Cochet (radiologist, CHU de Bordeaux).
The PhD student will test the new method with clinical data and develop it further. In a first stage, existing data can be used for an initial test. Then, prototype software will have to be developed to apply the method in a clinical setting. With the help of an electrical engineer some hardware development will be needed for interfacing. The PhD student will be present during interventions to operate and evaluate the software. Further development of algorithms is thinkable, as new ideas are likely to appear. Computer simulations can be performed if needed to support this work. The PhD student will study the relevant literature, and in collaboration with the project partners will write papers and give conference presentations to publish the results obtained.
The project should result in the writing of a PhD thesis and two or more publications in peer-reviewed international scientific journals, and the obtention of a PhD degree at the Université de Bordeaux.
Technical skills and level required : programming in compiled and scripting languages; basic mathematics
Languages : English
Relational skills : ability to organize and work with others
Other values appreciated : design and implementation of graphical user interfaces, digital electronics
- Subsidised catering service
- Partially-reimbursed public transport
- – 1982€ (before tax) / month the first & second years
- – 2085€ (before tax) / month the third year
Theme/Domain : Modeling and Control for Life Sciences
Town/city : Talence
Inria Center : CRI Bordeaux – Sud-Ouest
Starting date : 3/1/18
Duration of contract : 3 years
Deadline to apply : 12/15/17
Inria Team : CARMEN
Potse Mark / firstname.lastname@example.org
The keys to success
The project requires good skills in informatics and basic notions of electronics and signal processing, as witnessed by an MSc or equivalent degree in informatics, physics, or a related field. It is crucial that the candidate is open to interdisciplinary work and will take an interest in cardiology and biomedical engineering. Facility with linear algebra would be a strength. An important part of the work will take place in a clinical environment and will require collaboration with physicians, nurses, engineers, and fellow scientists. Applicants must have a working proficiency in English and, if they do not speak French, be prepared to learn the language at an intermediate level.
Conditions for application
To apply, please provide :
- Cover letter
- Letter(s) of recommendation, where applicable
- Transcript of the Master’s degree
Defence Security :
This position is likely to be situated in a restricted area (ZRR), as defined in Decree No. 2011-1425 relating to the protection of national scientific and technical potential (PPST).Authorisation to enter an area is granted by the director of the unit, following a favourable Ministerial decision, as defined in the decree of 3 July 2012 relating to the PPST. An unfavourable Ministerial decision in respect of a position situated in a ZRR would result in the cancellation of the appointment.
Recruitment Policy :
As part of its diversity policy, all Inria positions are accessible to people with disabilities.